Protocol and consent for intratympanic injection
Article Sidebar
Main Article Content
Abstract
The intratympanic injection is used to treat cochleovestibular symptoms associated with inner ear diseases such as Ménière’s disease or sudden sensorineural hearing loss. The most commonly used drugs are corticosteroids and aminoglycosides, and recently studies have been published on the use of N-acetylcysteine.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Este artículo es publicado por la Revista Acta de Otorrinolaringología & Cirugía de Cabeza y Cuello.
Este es un artículo de acceso abierto, distribuido bajo los términos de la LicenciaCreativeCommons Atribución-CompartirIgual 4.0 Internacional.( http://creativecommons.org/licenses/by-sa/4.0/), que permite el uso no comercial, distribución y reproducción en cualquier medio, siempre que la obra original sea debidamente citada.
eISSN: 2539-0856
ISSN: 0120-8411
References
Banerjee A, Parnes LS. The biology of intratympanic drug administration and pharmacodynamics of round window drug absorption. Otolaryngol Clin North Am. 2004;37(5):1035-51. doi: 10.1016/j.otc.2004.04.003
Sarafraz Z, Ahmadi A, Daneshi A. Transtympanic Injections of N-acetylcysteine and Dexamethasone for Prevention of Cisplatin Induced Ototoxicity: Double Blind Randomized Clinical Trial. Int Tinnitus J. 2018;22(1):40-45. doi: 10.5935/0946-5448.20180007
Sturm JJ, Maurrasse SE, Golub JS. Intratympanic steroid injection. Oper Tech Otolayngol Head Neck Surg. 2021;32(2):92–8. doi:10.1016/j.otot.2021.05.005
Ordóñez Ordóñez LE, Mojica Rojas AM. Fisiología coclear. Acta otorrinolaringol cir cabeza cuello. 2017;43(3):187-210. doi: 10.37076/acorl.v43i3.29
Lukashkin AN, Sadreev II, Zakharova N, Russell IJ, Yarin YM. Local Drug Delivery to the Entire Cochlea without Breaching Its Boundaries. iScience. 2020;23(3):100945. doi: 10.1016/j.isci.2020.100945
El Kechai N, Agnely F, Mamelle E, Nguyen Y, Ferrary E, Bochot A. Recent advances in local drug delivery to the inner ear. Int J Pharm. 2015;494(1):83-101. doi: 10.1016/j.ijpharm.2015.08.015
Nyberg S, Abbott NJ, Shi X, Steyger PS, Dabdoub A. Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier. Sci Transl Med. 2019;11(482):eaao0935. doi: 10.1126/scitranslmed.aao0935
Hamid M, Trune D. Issues, indications, and controversies regarding intratympanic steroid perfusion. Curr Opin Otolaryngol Head Neck Surg. 2008;16(5):434-40. doi: 10.1097/MOO.0b013e32830ce796
Patel M. Intratympanic corticosteroids in Ménière’s disease: A mini-review. J Otol. 2017;12(3):117-124. doi: 10.1016/j.joto.2017.06.002
Devantier L, Djurhuus BD, Hougaard DD, Händel MN, Guldfred FL, Schmidt JH, et al. Intratympanic Steroid for Menière’s Disease:
A Systematic Review. Otol Neurotol. 2019;40(6):806-12. doi: 10.1097/MAO.0000000000002255
Chandrasekhar SS, Tsai Do BS, Schwartz SR, Bontempo LJ, Faucett EA, Finestone SA, et al. Clinical Practice Guideline: Sudden Hearing Loss (Update). Otolaryngol Head Neck Surg. 2019;161(1_suppl):S1-S45. doi: 10.1177/0194599819859885
Staecker H, Morelock M, Kramer T, Chrbolka P, Ahn JH, Meyer T. Safety of Repeated-Dose Intratympanic Injections with AM-101 in Acute Inner Ear Tinnitus. Otolaryngol Head Neck Surg. 2017;157(3):478-487. doi: 10.1177/0194599817711378
Bodmer D, Morong S, Stewart C, Alexander A, Chen JM, Nedzelski JM. Long-term vertigo control in patients after intratympanic gentamicin instillation for Ménière’s disease. Otol Neurotol. 2007;28(8):1140-4. doi: 10.1097/mao.0b013e31815aea05
Liu YC, Chi FH, Yang TH, Liu TC. Assessment of complications due to intratympanic injections. World J Otorhinolaryngol Head Neck Surg. 2016;2(1):13-6. doi: 10.1016/j.wjorl.2015.11.001
de Cates C, Winters R. Intratympanic Steroid Injection. [Actualizado el 4 de julio de 2023]. En: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK567708/